Adenosine signalling to astrocytes coordinates brain metabolism and function.

ABSTRACT: Brain computation performed by billions of nerve cells relies on a sufficient and uninterrupted nutrient and oxygen supply^1,2. Astrocytes, the ubiquitous glial neighbours of neurons, govern brain glucose uptake and metabolism^3,4, but the exact mechanisms of metabolic coupling between neurons and astrocytes that ensure on-demand support of neuronal energy needs are not fully understood^5,6. Here we show, using experimental in vitro and in vivo animal models, that neuronal activity-dependent metabolic activation of astrocytes is mediated by neuromodulator adenosine acting on astrocytic A2B receptors. Stimulation of A2B receptors recruits the canonical cyclic adenosine 3',5'-monophosphate-protein kinase A signalling pathway, leading to rapid activation of astro

SUBMITTER: Theparambil SM 

PROVIDER: S-EPMC11291286 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature