Psilocybin desynchronizes the human brain.

ABSTRACT: A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials^1-4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus^5-8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6-12 months later. Psilocybin massively disrupted f

SUBMITTER: Siegel JS 

PROVIDER: S-EPMC11291293 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature