Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study.

ABSTRACT:

Background

Genome-wide association studies (GWASs) have identified 38 loci associated with ulcerative colitis (UC) susceptibility, but the risk genes and their biological mechanisms remained to be comprehensively elucidated.

Methods

Multi-marker analysis of genomic annotation (MAGMA) software was used to annotate genes on GWAS summary statistics of UC from FinnGen database. Genetic analysis was performed to identify risk genes. Cross-tissue transcriptome-wide association study (TWAS) using the unified test for molecular signatures (UTMOST) was performed to compare GWAS summary statistics with gene expression matrix (from Genotype-Tissue Expression Project) for data integration. Subsequently, we used FUSION software to select key genes from the individual tissues. Additionall

SUBMITTER: Ren S 

PROVIDER: S-EPMC11291327 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature