Circulating glutamine/glutamate ratio is closely associated with type 2 diabetes and its associated complications.

ABSTRACT:

Objective

This study aims to conduct a comprehensive investigation of the serum amino acid profiles of individuals with type 2 diabetes (T2D) and its related complications.

Methods

Patients with T2D were enrolled in this study. Sixteen kinds of common amino acids in the fasting circulating were assessed through liquid chromatography-mass spectrometry (LC-MS). Subsequently, correlation, regression analyses, and receiver operating characteristic (ROC) curves were conducted to assess the associations between amino acids and clinical indicators.

Results

Thirteen different kinds of amino acids were identified in diabetic patients, as compared with normal controls. The Glutamine/Glutamate (Gln/Glu) ratio was negatively correlated with BMI, HbA1c, serum uric acid, and the tr

SUBMITTER: Han F 

PROVIDER: S-EPMC11291334 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature