Prediction of overall survival in patients with locally advanced pancreatic cancer using longitudinal diffusion-weighted MRI.

ABSTRACT:

Background and purpose

Biomarkers for prediction of outcome in patients with pancreatic cancer are wanted in order to personalize the treatment. This study investigated the value of longitudinal diffusion-weighted magnetic resonance imaging (DWI) for prediction of overall survival (OS) in patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy (SBRT).

Materials and methods

The study included 45 patients with LAPC who received 5 fractions of 10 Gy on a 1.5T MRI-Linac. DWI was acquired prior to irradiation at each fraction. The analysis included baseline values and time-trends of the apparent diffusion coefficient (ADC) and DWI parameters obtained using a decomposition method. A multivariable Cox proportional hazards model for OS was

SUBMITTER: Bisgaard ALH 

PROVIDER: S-EPMC11291378 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature