Physical Frailty, Genetic Predisposition, and Incident Heart Failure.

ABSTRACT:

Background

There is growing interest in the intersection of frailty and heart failure (HF); however, large-sample longitudinal studies in the general population are lacking.

Objectives

The goal of this study was to examine the longitudinal relationship between frailty and incident HF, and whether age and genetic predisposition could modify this association.

Methods

This prospective cohort study included 340,541 participants (45.7% male; mean age 55.9 ± 8.1 years) free of HF at baseline in the UK Biobank. Frailty was assessed by using the Fried frailty phenotype and included weight loss, exhaustion, low physical activity, slow gait speed, and low grip strength. The weighted polygenetic risk score was calculated. Cox models were used to estimate these associations and t

SUBMITTER: Shi Q 

PROVIDER: S-EPMC11291395 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature