A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge.

ABSTRACT: In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all current approved human and veterinary vaccines are derived from genotype (G) III JEV strains, we used the recently described insect-specific Binjari virus (BinJV) chimeric flavivirus vaccine technology to produce a JEV GIV vaccine candidate. Herein we describe the production of a chimeric virus displaying the structural prM and E proteins of a JEV GIV isolate obtained from a stillborn piglet (JEV_NSW/22) in the genomic backbone of BinJV (BinJ/JEV_NSW/22-prME). BinJ/JEV_NSW/22-prME was shown to be antigenically indistinguishable

SUBMITTER: Harrison JJ 

PROVIDER: S-EPMC11291493 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature