No requirement of perioperative glucocorticoid replacement in patients with endogenous Cushing's syndrome - a pilot study.

ABSTRACT:

Purpose

Surgical therapy represents the first-line treatment for endogenous Cushing's syndrome (CS). While postoperative glucocorticoid replacement is mandatory after surgical remission, the role of perioperative glucocorticoid therapy is unclear.

Methods

We recruited patients with central or adrenal CS in whom curative surgery was planned and patients who underwent pituitary surgery for other reasons than CS as a control group. Patients did not receive any perioperative glucocorticoids until the morning of the first postoperative day. We performed blood samplings in the morning of surgery, immediately after surgery, in the evening of the day of surgery, and in the morning of the first and third postoperative day before any morning glucocorticoid intake. We continued clinica

SUBMITTER: Trummer C 

PROVIDER: S-EPMC11291516 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature