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Exploring the association between type 2 diabetes and fecal incontinence in american adults: insights from a large cross-sectional study.

ABSTRACT: The relationship between fecal incontinence (FI) and type 2 diabetes (T2D) has been well recognized, but a comprehensive understanding of this relationship is lacking, taking into account demographic factors and lifestyle variables. Using a cross-sectional approach, 13,510 adults aged 20 years and older were identified from the 2005-2010 National Health and Nutrition Examination Survey. Multivariate logistic regression models were used to calculate the adjusted odds ratios (ORs), and further subgroup analyses and propensity score analysis were performed to ensure stable results. Among 13,510 adults, 11.2% had T2D, and 8.8% had FI. We found a strong T2D-FI link (OR: 1.30; 95% CI: 1.09-1.54, P < 0.001), even after adjusting for covariates. Age > 45 was a critical factor, with a stronger T2D-FI association. Sedentary behavior (OR: 1.41; 95% CI: 1.15-1.73) in T2D patients were associated with FI. Our study highlights the significant T2D-FI link in US adults, especially in older T2D patients. Lifestyle changes may reduce FI risk. More research is needed for causality and mechanisms.

SUBMITTER: Li LC

PROVIDER: S-EPMC11291540 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Exploring the association between type 2 diabetes and fecal incontinence in american adults: insights from a large cross-sectional study.

Li Lun-Chao LC Liang Li-Ming LM Ji Hong-Ye HY Zhang Can C Wang Man M Liu Hong-Sheng HS

International journal of colorectal disease 20240731 1

<h4>Background</h4>The relationship between fecal incontinence (FI) and type 2 diabetes (T2D) has been well recognized, but a comprehensive understanding of this relationship is lacking, taking into account demographic factors and lifestyle variables.<h4>Methods</h4>Using a cross-sectional approach, 13,510 adults aged 20 years and older were identified from the 2005-2010 National Health and Nutrition Examination Survey. Multivariate logistic regression models were used to calculate the adjusted ...[more]

PMID: 39085653

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Project description:BackgroundPrevious studies have revealed the impact of heavy metals (HMs) on gut microbiota and intestinal structure. However, the relationship between HMs and fecal incontinence (FI) remains unclear. Therefore, this study aims to evaluate the association between blood HMs exposure and FI.MethodsData for this study were obtained from the 2005-2010 cycles of National Health and Nutrition Examination Survey (NHANES). Information regarding FI was retrieved from the Bowel Health Questionnaire, while data on HMs were collected through laboratory examinations. Weighted logistic regression, two-indices weighted quantile sum (2iWQS), quantile g-computation (qgcomp), and restricted cubic splines (RCS) were employed to explore the relationships between blood levels of cadmium (Cd), lead (Pb), and mercury (Hg) and FI. Additionally, Subgroup analyses were conducted to discern specific associations within distinct populations.ResultsA total of 12,142 participants aged 20 years and above were included in this study. Weighted logistic regression indicated a positive association between Cd (Crude model: OR = 1.21, 95% CI: 1.09-1.35, p < 0.001) and Pb (Crude model: OR = 1.01, 95% CI: 1.01-1.02, p < 0.001) with FI. After adjusting for all covariates, the positive associations remained significant for Cd (Model 2: Q1 vs. Q3, OR = 1.38, 95% CI: 1.04-1.83, p = 0.026) and Pb (Model 2: OR = 1.01, 95% CI: 1.00-1.01, p = 0.004). The 2iWQS regression analysis demonstrated a positive correlation between the mixture of three blood HMs and FI (OR = 1.18, 95% CI: 1.05-1.32, p = 0.005), with Cd having the highest weight among the metals (0.76). The qgcomp analysis confirmed this finding (OR = 1.12, 95% CI: 1.01-1.26, p = 0.036; weight = 0.72). Subgroup analysis revealed that the positive association between Cd and FI was more pronounced among males; Mexican Americans; those with a poverty income ratio (PIR) > 2; individuals with college or above education; overweight participants; never-smokers; heavy drinkers; those with hypertension; and non-diabetes individuals. Conversely, the association between Pb and FI was stronger among participants aged 40-60, overweight participants, and never-smokers.ConclusionExposure to blood HMs, particularly Cd, is associated with FI in American adults. Future research should focus on elucidating the causal relationships and underlying mechanisms.

Dataset Information

Exploring the association between type 2 diabetes and fecal incontinence in american adults: insights from a large cross-sectional study.

Publications

Exploring the association between type 2 diabetes and fecal incontinence in american adults: insights from a large cross-sectional study.

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