Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis.

ABSTRACT:

Purpose

To investigate the relationship between abnormal glucose metabolism, type 2 diabetes (T2D), and periodontal disease (PER) independent of Body Mass Index (BMI), we employed a genome-wide cross-trait approach to clarify the association.

Methods

Our study utilized the most extensive genome-wide association studies conducted for populations of European ancestry, including PER, T2D, fasting glucose, fasting insulin, 2-hour glucose after an oral glucose challenge, HOMA-β, HOMA-IR (unadjusted or adjusted for BMI) and HbA1c.

Results

With this approach, we were able to identify pleiotropic loci, establish expression-trait associations, and quantify global and local genetic correlations. There was a significant positive global genetic correlation between T2D (r_g

SUBMITTER: Wu KCH 

PROVIDER: S-EPMC11291565 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature