Exceptions to the rule: When does resistance evolution not undermine antibiotic therapy in human bacterial infections?

ABSTRACT: The use of antibiotics to treat bacterial infections often imposes strong selection for antibiotic resistance. However, the prevalence of antibiotic resistance varies greatly across different combinations of pathogens and drugs. What underlies this variation? Systematic reviews, meta-analyses, and literature surveys capable of integrating data across many studies have tried to answer this question, but the vast majority of these studies have focused only on cases where resistance is common or problematic. Yet much could presumably be learned from the cases where resistance is infrequent or absent. Here we conducted a literature survey and a systematic review to study the evolution of antibiotic resistance across a wide range of pathogen-by-drug combinations (57 pathogens and 53 antibiotics

SUBMITTER: Bhattacharya A 

PROVIDER: S-EPMC11291617 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature