Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England.

ABSTRACT: The first dose of COVID-19 vaccines led to an overall reduction in cardiovascular events, and in rare cases, cardiovascular complications. There is less information about the effect of second and booster doses on cardiovascular diseases. Using longitudinal health records from 45.7 million adults in England between December 2020 and January 2022, our study compared the incidence of thrombotic and cardiovascular complications up to 26 weeks after first, second and booster doses of brands and combinations of COVID-19 vaccines used during the UK vaccination program with the incidence before or without the corresponding vaccination. The incidence of common arterial thrombotic events (mainly acute myocardial infarction and ischaemic stroke) was generally lower after each vaccine dose, brand and

SUBMITTER: Ip S 

PROVIDER: S-EPMC11291640 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature