Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice.

ABSTRACT: Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties. Following prolonged administration of fluoxetine in male mice, we showed that fluoxetine increases the number of muscle stem cells and muscle angiogenesis, associated with positive changes in skeletal muscle function. Fluoxetine also improved skeletal muscle regeneration after single and multiples injuries with an increased muscle stem cells pool and vessel density associated with reduced fibrotic lesions and inflammation. Mice devoid of peripheral serotonin treated wi

SUBMITTER: Fefeu M 

PROVIDER: S-EPMC11291725 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature