Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation.

ABSTRACT: The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, which occurs in shift workers, has been linked to an increased risk of gastrointestinal diseases, including IBD. The peripheral circadian clock in intestinal epithelial cells (IECs) was previously shown to balance gastrointestinal homeostasis by regulating the microbiome. Here, we demonstrated that the intestinal clock is disrupted in an IBD-relevant mouse model (IL-10^-/-). A lack of the intestinal clock gene (Bmal1) in intestinal epithelial cells (IECs) in a chemically and a novel genetically induced colitis model (DSS, Bmal1^IEC-/-xIL-10^-/-) promoted colitis and dramatically reduced survival rates.

SUBMITTER: Niu Y 

PROVIDER: S-EPMC11291886 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature