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Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.

ABSTRACT: The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome, cytokine, and transcriptome profiles of repeated samples from hospitalized COVID-19 patients and uninfected controls, and leveraged clinical information and post-hoc confounder analysis. Severe COVID-19 was associated with a depletion of beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance was mainly linked to antibiotic use. COVID-19 severity was also associated with enhanced plasma concentrations of kynurenine and reduced levels of several other tryptophan metabolites, lysophosphatidylcholines, and secondary bile acids. Moreover, reduced concentrations of various tryptophan metabolites were associated with depletion of Faecalibacterium, and tryptophan decrease and kynurenine increase were linked to enhanced production of inflammatory cytokines. Collectively, our study identifies correlated microbiome and metabolome alterations as a potential contributor to inflammatory dysregulation in severe COVID-19.

SUBMITTER: Essex M

PROVIDER: S-EPMC11291933 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.

Essex Morgan M Millet Pascual-Leone Belén B Löber Ulrike U Kuhring Mathias M Zhang Bowen B Brüning Ulrike U Fritsche-Guenther Raphaela R Krzanowski Marta M Fiocca Vernengo Facundo F Brumhard Sophia S Röwekamp Ivo I Anna Bielecka Agata A Lesker Till Robin TR Wyler Emanuel E Landthaler Markus M Mantei Andrej A Meisel Christian C Caesar Sandra S Thibeault Charlotte C Corman Victor M VM Marko Lajos L Suttorp Norbert N Strowig Till T Kurth Florian F Sander Leif E LE Li Yang Y Kirwan Jennifer A JA Forslund Sofia K SK Opitz Bastian B

NPJ biofilms and microbiomes 20240801 1

The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome, cytokine, and transcriptome profiles of repeated samples from hospitalized COVID-19 patients and uninfected controls, and leveraged clinical information and post-hoc confounder analysis. Severe COVID-19 was associated with a depletion of beneficial intestinal ...[more]

PMID: 39085233

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Dataset Information

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.

Publications

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.

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