Metal-carbene-guided twofold cross-coupling of ethers with chromium catalysis.

ABSTRACT: Coupling by metal-carbene transfer enables the formation of several different bonds at the carbenoid site, enabling prochiral C_sp³ centers that are fundamental three-dimensional substructures for medicines to be forged with increased efficiency. However, strategies using bulk chemicals are rare because of the challenge of breaking two unactivated geminal bonds. Herein, we report the reactivity of ethers to form metal-carbene intermediate by cleavage of α-C_sp³-H/C_sp³-O bonds, which achieve selective coupling with arylmagnesium bromides and chlorosilanes. These couplings are catalysed by cyclic (alkyl)(amino)carbene-chromium complex and enable the one-step formation of 1,n-arylsilyl alcohols and α-arylated silanes. Mechanistic

SUBMITTER: Fan F 

PROVIDER: S-EPMC11292013 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature