Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk.

ABSTRACT:

Purpose

Clonal hematopoiesis (CH) is thought to be the origin of myeloid neoplasms (MN). Yet, our understanding of the mechanisms driving CH progression to MN and clinical risk prediction of MN remains limited. The human proteome reflects complex interactions between genetic and epigenetic regulation of biological systems. We hypothesized that the plasma proteome might predict MN risk and inform our understanding of the mechanisms promoting MN development.

Experimental design

We jointly characterized CH and plasma proteomic profiles of 46,237 individuals in the UK Biobank at baseline study entry. During 500,036 person-years of follow-up, 115 individuals developed MN. Cox proportional hazard regression was used to test for an association between plasma protein levels and MN r

SUBMITTER: Tran D 

PROVIDER: S-EPMC11292192 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature