Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas.

ABSTRACT:

Purpose

The landscape of extracellular matrix (ECM) alterations in soft tissue sarcomas (STS) remains poorly characterized. We aimed to investigate the tumor ECM and adhesion signaling networks present in STS and their clinical implications.

Experimental design

Proteomic and clinical data from 321 patients across 11 histological subtypes were analyzed to define ECM and integrin adhesion networks. Subgroup analysis was performed in leiomyosarcomas (LMS), dedifferentiated liposarcomas (DDLPS), and undifferentiated pleomorphic sarcomas (UPS).

Results

This analysis defined subtype-specific ECM profiles including enrichment of basement membrane proteins in LMS and ECM proteases in UPS. Across the cohort, we identified three distinct coregulated ECM networks which are assoc

SUBMITTER: Pankova V 

PROVIDER: S-EPMC11292195 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature