Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism.

ABSTRACT: Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum of anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models of insulin resistance and reveal a consistent decrease in the level of the mitochondrial processing peptidase miPEP.

Objective

To determine the role of miPEP in insulin resistance.

Methods

To experimentally test this observation, we generated adipocyte-specific miPEP knockout mice to interrogate its role in the aetiology of insulin resistance.

Results

We observed a strong phenotype characterised by enhanced insulin sensitivity and reduced adiposity, despite normal food intake and physical activity. Strikingly, these phenotypes vanished when mice

SUBMITTER: Diaz-Vegas A 

PROVIDER: S-EPMC11292358 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature