Circulating netrin-1 levels are reduced and related to corneal nerve fiber loss in patients with diabetic neuropathy.

ABSTRACT:

Aims/introduction

Deficiency of neurotropic factors is implicated in diabetic neuropathy (DN). Netrin-1 is a neurotropic factor, but its association with DN has not been explored. We have assessed the association between serum netrin-1 levels and early diabetic neuropathy assessed by quantifying corneal nerve fiber loss using corneal confocal microscopy.

Materials and methods

A total of 72 participants with type 2 diabetes, without and with corneal nerve fiber loss (DN- n = 42, DN+ n = 30), and 45 healthy controls were studied. Serum netrin-1 levels were measured by enzyme-linked immunosorbent assay, and corneal nerve morphology was assessed using corneal confocal microscopy.

Results

Corneal nerve fiber density, branch density, fiber length and serum netrin-1 levels w

SUBMITTER: Mondal A 

PROVIDER: S-EPMC11292387 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature