Distinct circulating cytokine levels in patients with angiography-proven coronary artery disease compared to disease-free controls.

ABSTRACT:

Background

Systemic inflammation has a critical role in the development of symptomatic coronary artery disease (CAD). Identification of inflammatory pathways may provide a platform for novel therapeutic approaches. We sought to determine whether there are differences in circulating cytokine profiles between patients with CAD and disease-free controls as well as according to the severity of the disease.

Methods

Case-control study's population consisted of 452 patients who underwent diagnostic invasive coronary angiography due to clinical indications. We measured the serum concentrations of 48 circulating cytokines. Extent of CAD was assessed using the SYNTAX Score in 116 patients. Cytokine differences between groups were tested using Mann-Whitney U test and association

SUBMITTER: Maaniitty E 

PROVIDER: S-EPMC11292512 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature