Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration.

ABSTRACT:

Objective

Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models. However, whether particular metabolites causally affect the disease has yet to be established.

Design

A 3-tiered analysis of blood metabolites in the United Kingdom (UK) Biobank cohort to identify metabolites that differ in AMD patients with evidence for a putatively causal role in AMD.

Participants

A total of 72 376 donors from the UK Biobank cohort including participants with

SUBMITTER: Farashi S 

PROVIDER: S-EPMC11292535 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature