Vitamin B₃ Intercalated in Layered Double Hydroxides: A Drug Delivery System for Metabolic Regulation.

ABSTRACT: The organic compound niacin or nicotinic acid, also known as vitamin B₃ (VitB₃), is essential for human nutrition and metabolic regulation. However, in high doses, it can provoke side effects, such as hyperglycemia, liver damage, and flushing. Development of a controlled release system that slowly releases VitB₃ into the organism would avoid high dosing peaks, thus contributing to decrease the occurrence of side effects in nutritional supplementation. Here, we show that the slow and controlled release of VitB₃ in an acid environment can be achieved via its intercalation in layered double hydroxides (LDHs). The synthesis of a ZnAl-VitB₃ system is shown, in which VitB₃ is intercalated in a ZnAl LDH. The presence of VitB_3<

SUBMITTER: Lisevski CI 

PROVIDER: S-EPMC11292643 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature