Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System.

ABSTRACT: Prolonged or excessive use of acid suppressants may increase the risk of Clostridioides difficile infection (CDI) by altering the intestinal microecosystem. Vonoprazan, a novel potassium-competitive acid blocker, exhibits a faster and more sustained acid-suppressive effect than proton pump inhibitors (PPIs). Therefore, vonoprazan may have a greater impact on the gut microbiota, potentially resulting in CDI. This study aimed to explore the potential relationship between acid suppressants and CDI by the Japan Adverse Drug Event Report (JADER) and the FDA Adverse Event Reporting System (FAERS) databases. A retrospective analysis of the JADER and FAERS databases was examined by disproportionality analysis. We performed signal detection analyses of CDI induced by vonoprazan and PPIs using the J

SUBMITTER: Ouyang M 

PROVIDER: S-EPMC11292713 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature