Retrospective Cohort Study of Additional Procedures and Transplant-Free Survival for Patients With Functionally Single Ventricle Disease Undergoing Staged Palliation in England and Wales.

ABSTRACT:

Background

Reinterventions may influence the outcomes of children with functionally single-ventricle (f-SV) congenital heart disease.

Methods and results

We undertook a retrospective cohort study of children starting treatment for f-SV between 2000 and 2018 in England, using the national procedure registry. Patients were categorized based on whether they survived free of transplant beyond 1 year of age. Among patients who had transplant-free survival beyond 1 year of age, we explored the relationship between reinterventions in infancy and the outcomes of survival and Fontan completion, adjusting for complexity. Of 3307 patients with f-SV, 909 (27.5%), had no follow-up beyond 1 year of age, among whom 323 (35.3%) had ≥1 reinterventions in infancy. A total of 2398 (72.5%) pati

SUBMITTER: Huang Q 

PROVIDER: S-EPMC11292744 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature