Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic ApoE^-/- Mice.

ABSTRACT:

Background

Atherosclerosis is highly prevalent in people with chronic kidney disease (CKD), including those receiving peritoneal dialysis (PD). Although it is lifesaving, PD induces profound systemic inflammation, which may aggravate atherosclerosis. Therefore, the hypothesis is that this PD-induced inflammation aggravates atherosclerosis via immune cell activation.

Methods and results

ApoE^-/- mice were subjected to a 5/6 nephrectomy to induce CKD. Three weeks later, mice were fed a high-cholesterol diet. Half of the nephrectomized mice then received daily peritoneal infusions of 3.86% Physioneal for 67 further days (CKD+PD) until the end of the experiment, and were compared with mice without CKD. Sham operated and PD-only mice were additional contro

SUBMITTER: Kane J 

PROVIDER: S-EPMC11292770 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature