Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice.

ABSTRACT: Obesity is a chronic disease caused by excessive fat accumulation that impacts the body and brain health. Insufficient leptin or leptin receptor (LepR) is involved in the disease pathogenesis. Leptin is involved with several neurological processes, and it has crucial developmental roles. We have previously demonstrated that leptin deficiency in early life leads to permanent developmental problems in young adult mice, including an imbalance in energy homeostasis, alterations in melanocortin and the reproductive system and a reduction in brain mass. Given that in humans, obesity has been associated with brain atrophy and cognitive impairment, it is important to determine the long-term consequences of early-life leptin deficiency on brain structure and memory function. Here, we demonstrate th

SUBMITTER: Fernandes C 

PROVIDER: S-EPMC11292908 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature