Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?

ABSTRACT:

Background

Fatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD.

Methods

Notably, 36 patients with moderate-to-severe SVD underwent neuropsychometric testing, combined positron emission tomography and magnetic resonance imaging (PET-MRI) scan, and blood draw for the analysis of inflammatory blood biomarkers. Microglial signal was taken as a proxy for neuroinflammation, assessed with radioligand ¹¹C-PK11195. Of these, 30 subjects had full PET datasets for analysis. We assessed global ¹¹C-PK11195 binding and hotspots of ^11</

SUBMITTER: Jolly AA 

PROVIDER: S-EPMC11292988 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature