Meta-analysis identifies common gut microbiota associated with multiple sclerosis.

ABSTRACT:

Background

Previous studies have identified a diverse group of microbial taxa that differ between patients with multiple sclerosis (MS) and the healthy population. However, interpreting findings on MS-associated microbiota is challenging, as there is no true consensus. It is unclear whether there is gut microbiota commonly altered in MS across studies.

Methods

To answer this, we performed a meta-analysis based on the 16S rRNA gene sequencing data from seven geographically and technically diverse studies comprising a total of 524 adult subjects (257 MS and 267 healthy controls). Analysis was conducted for each individual study after reprocessing the data and also by combining all data together. The blocked Wilcoxon rank-sum test and linear mixed-effects regression were used t

SUBMITTER: Lin Q 

PROVIDER: S-EPMC11293023 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature