Maternal hypothyroidism and subsequent metabolic outcomes in children: a systematic review and meta-analysis.

ABSTRACT: As the fetus relies on maternal thyroid hormones in early pregnancy, maternal hypothyroidism plays an important role in fetal development. However, the association between maternal hypothyroidism and metabolic disease in offspring is unclear. To examine the association between maternal hypothyroidism in pregnancy and metabolic outcomes (obesity, hypertension, type 2 diabetes mellitus, and dyslipidemia) in children < 18 years. We systematically searched 5 databases from inception to May 2023. Eligible studies included cohort, case-control, and randomized controlled trials involving children born to mothers with or without hypothyroidism in pregnancy. Data were pooled across studies using random-effects models for outcomes reported in at least three studies. Quality assessment was performed

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11293156 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature