Ontology highlight
ABSTRACT:
SUBMITTER: Fiorenza M
PROVIDER: S-EPMC11293340 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Fiorenza Matteo M Checa Antonio A Sandsdal Rasmus M RM Jensen Simon B K SBK Juhl Christian R CR Noer Mikkel H MH Bogh Nicolai P NP Lundgren Julie R JR Janus Charlotte C Stallknecht Bente M BM Holst Jens Juul JJ Madsbad Sten S Wheelock Craig E CE Torekov Signe S SS
Cell reports. Medicine 20240702 7
Weight loss is often followed by weight regain. Characterizing endocrine alterations accompanying weight reduction and regain may disentangle the complex biology of weight-loss maintenance. Here, we profile energy-balance-regulating metabokines and sphingolipids in adults with obesity undergoing an initial low-calorie diet-induced weight loss and a subsequent weight-loss maintenance phase with exercise, glucagon-like peptide-1 (GLP-1) analog therapy, both combined, or placebo. We show that circu ...[more]