The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques.

ABSTRACT:

Background and purpose

To compare secondary malignancy risks of modern proton and photon therapy techniques for locally advanced breast cancer.

Methods and materials

We utilized dosimetric data from 34 [10 photon-VMAT, 10 photon-3DCRT, 14 pencil beam scanning proton (PBS)] breast cancer patients who received comprehensive nodal irradiation. Employing a model based on organ equivalent dose to account for both inhomogeneous organ dose distributions and non-linear functional dose relationships, we estimated excess absolute risk, excess relative risk, and lifetime attributable risk (LAR) for secondary malignancies. The model uses dose distribution, number of fractions, age at exposure, attained age, the linear-quadratic dose response relationship for cell survival, repopulation

SUBMITTER: Paganetti H 

PROVIDER: S-EPMC11293368 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature