A real-world data analysis of electronic health records to investigate the associations of predominant negative symptoms with healthcare resource utilisation, costs and treatment patterns among patients with schizophrenia.

ABSTRACT: Negative symptoms in schizophrenia are associated with significant illness burden. We sought to investigate clinical outcomes for patients with schizophrenia who present with predominant negative symptoms (PNS) vs without PNS. Retrospective analysis of electronic health record (EHR) data. 25 US providers of mental healthcare. 4444 adults with schizophrenia receiving care between 1999 and 2020. PNS defined as ≥3 negative symptoms and ≤3 positive symptoms recorded in EHR data at the time of the first recorded schizophrenia diagnosis (index date). Symptom data were ascertained using natural language processing applied to semistructured free text records documenting the mental state examination. A matched sample (1:1) of patients without PNS was used to compare outcomes. Follow-up data were ob

SUBMITTER: Patel R 

PROVIDER: S-EPMC11293408 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature