Effects of perioperative dexmedetomidine on delayed graft function following renal transplant: a systematic review and meta-analysis.

ABSTRACT:

Background

Dexmedetomidine, a highly selective alpha-2 adrenoceptor agonist with sedative and analgesic effects, has been suggested in recent studies to possess renoprotective properties. Dexmedetomidine may reduce the incidence of delayed graft function and contribute to effective pain control post-renal transplantation. The primary objective of this systematic review was to assess whether dexmedetomidine decreases the occurrence of delayed graft function in renal transplant patients.

Methods

Databases including MEDLINE, EMBASE, and CENTRAL were comprehensively searched from their inception until March 2023. The inclusion criteria covered all Randomized Clinical Trials (RCTs) and observational studies comparing dexmedetomidine to control in adult patients undergoing renal t

SUBMITTER: Ng KT 

PROVIDER: S-EPMC11293508 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature