Single-cell discovery of m⁶A RNA modifications in the hippocampus.

ABSTRACT: N ⁶-Methyladenosine (m⁶A) is a prevalent and highly regulated RNA modification essential for RNA metabolism and normal brain function. It is particularly important in the hippocampus, where m⁶A is implicated in neurogenesis and learning. Although extensively studied, its presence in specific cell types remains poorly understood. We investigated m⁶A in the hippocampus at a single-cell resolution, revealing a comprehensive landscape of m⁶A modifications within individual cells. Through our analysis, we uncovered transcripts exhibiting a dense m⁶A profile, notably linked to neurological disorders such as Alzheimer's disease. Our findings suggest a pivotal role of m⁶A-containing transcripts, particularly in the

SUBMITTER: Feng S 

PROVIDER: S-EPMC11293556 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature