Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice.

ABSTRACT: Basolateral amygdala (BLA) is a key hub for affect in the brain,^1,2,3 and dysfunction within this area contributes to a host of psychiatric disorders.^4,5 BLA is extensively and reciprocally interconnected with frontal cortex,^6,7,8,9 and some aspects of its function are evolutionarily conserved across rodents, anthropoid primates, and humans.¹⁰ Neuron density in BLA is substantially lower in primates compared to murine rodents,¹¹ and frontal cortex (FC) is dramatically expanded in primates, particularly the more anterior granular and dysgranular areas.^12,13,1

SUBMITTER: Zeisler ZR 

PROVIDER: S-EPMC11293557 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature