Caffeine and kidney function at two years in former extremely low gestational age neonates.

ABSTRACT:

Background

Extremely low gestational age neonates (ELGANs) are at risk for chronic kidney disease. The long-term kidney effects of neonatal caffeine are unknown. We hypothesize that prolonged caffeine exposure will improve kidney function at 22-26 months.

Methods

Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates <28 weeks' gestation. Participants included if any kidney outcomes were collected at 22-26 months corrected age. Exposure was post-menstrual age of caffeine discontinuation.

Primary outcomes

'reduced eGFR' <90 ml/min/1.73 m², 'albuminuria' (>30 mg albumin/g creatinine), or 'elevated blood pressure' (BP) >95th %tile. A general estimating equation logistic regression model stratified by bronchopulmonary dysplasia (BPD)

SUBMITTER: Harer MW 

PROVIDER: S-EPMC11293578 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature