Association of IL13 polymorphisms with susceptibility to myocardial infarction: A case-control study in Chinese population.

ABSTRACT:

Background

Inflammatory cytokines play a major role in the pathogenesis of myocardial infarction (MI). Although information on the importance of interleukin 13 (IL13) in human MI is limited, it has been well documented in the mouse model. Genetic variation in the IL13 gene has been associated with the structure and expression of the IL13. In the present study, we hypothesized that IL13 common genetic variants would be associated with a predisposition to the development of MI.

Materials and methods

The present study enrolled 305 MI patients and 310 matched healthy controls. Common genetic polymorphisms in the IL13 gene (rs20541, rs1881457, and rs1800925) were genotyped using the TaqMan SNP genotyping method. Plasma levels of IL13 were measured using an enzyme-linked immunosor

SUBMITTER: Chen R 

PROVIDER: S-EPMC11293651 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature