Quantifying massively parallel microbial growth with spatially mediated interactions.

ABSTRACT: Quantitative understanding of microbial growth is an essential prerequisite for successful control of pathogens as well as various biotechnology applications. Even though the growth of cell populations has been extensively studied, microbial growth remains poorly characterised at the spatial level. Indeed, even isogenic populations growing at different locations on solid growth medium typically show significant location-dependent variability in growth. Here we show that this variability can be attributed to the initial physiological states of the populations, the interplay between populations interacting with their local environment and the diffusion of nutrients and energy sources coupling the environments. We further show how the causes of this variability change throughout the growth of

SUBMITTER: Borse F 

PROVIDER: S-EPMC11293690 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature