The association between METS-IR, an indirect index for insulin resistance, and lung cancer risk.

ABSTRACT:

Background

Insulin resistance has been reported to increase the risk of breast, prostate and colorectal cancer. However, the role of insulin resistance and its interaction with genetic risk in the development of lung cancer remains controversial. Therefore, we aimed to explore the association between a novel metabolic score for insulin resistance (METS-IR) and lung cancer risk.

Methods

A total of 395 304 participants without previous cancer at baseline were included. The Cox proportional hazards regression model was performed to investigate the association between METS-IR and lung cancer risk. In addition, a Mendelian randomization analysis was also performed to explore the causal relationship. The joint effects and additive interactions between METS-IR and polygenetic risk

SUBMITTER: Wang G 

PROVIDER: S-EPMC11293818 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature