TNF-α inhibitor use during pregnancy and the risk of preeclampsia: population-based cohort study.

ABSTRACT:

Background

Although the clinical importance of preeclampsia is widely recognized, few treatment options are available for prevention. TNF-α inhibitors have been hypothesized to potentially prevent the disease. We aimed to examine whether exposure to TNF-α inhibitors during pregnancy reduces the risk of preeclampsia.

Methods

We conducted a population-based pregnancy cohort study using nationwide samples of publicly (Medicaid data, 2000-2018) and commercially (MarketScan Research Database, 2003-2020) insured pregnant women linked to their liveborn infants. Exposure was ascertained based on a filled prescription or administration code for TNF-α inhibitors during the first and second trimester of pregnancy. The outcomes included early-onset preeclampsia, late-onset preeclampsia,

SUBMITTER: Adomi M 

PROVIDER: S-EPMC11293998 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature