Long-term insulin resistance is associated with frailty, frailty progression, and cardiovascular disease.

ABSTRACT:

Background

Insulin resistance and diabetes are associated with an increased risk of frailty, and frailty is associated with cardiovascular disease and premature mortality. We aim to investigate the impact of long-term insulin resistance trajectories on future frailty and cardiovascular risk among young adults.

Methods

In total, 3168 participants with a 30-year follow-up period. The baseline period covered the first 15 years as the exposure period. Insulin resistance was determined using the homeostasis model assessment for insulin resistance (HOMA-IR), and three trajectories (low, moderate, and high) were constructed. The subsequent 15 years constituted the event accrual period. Frailty was assessed using a deficit accumulation mode, and cardiovascular outcomes were obtained

SUBMITTER: Ke Z 

PROVIDER: S-EPMC11294012 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature