GDF-15 is associated with sarcopenia and frailty in acutely admitted older medical patients.

ABSTRACT:

Background

Growth differentiation factor-15 (GDF-15) has been associated with senescence, lower muscle strength, and physical performance in healthy older people. Still, it is not clear whether GDF-15 can be utilized as a biomarker of sarcopenia and frailty in the early stages of hospitalization. We investigated the association of plasma GDF-15 with sarcopenia and frailty in older, acutely admitted medical patients.

Methods

The present study is based on secondary analyses of cross-sectional data from the Copenhagen PROTECT study, a prospective cohort study including 1071 patients ≥65 years of age admitted to the acute medical ward at Copenhagen University Hospital, Bispebjerg, Denmark. Muscle strength was assessed using handgrip strength, and lean mass was assessed using dir

SUBMITTER: Kamper RS 

PROVIDER: S-EPMC11294026 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature