Creatinine, cystatin C, muscle mass, and mortality: Findings from a primary and replication population-based cohort.

ABSTRACT:

Background

Serum creatinine is used as initial test to derive eGFR and confirmatory testing with serum cystatin C is recommended when creatinine-based eGFR is considered less accurate due to deviant muscle mass. Low muscle mass is associated with increased risk of premature mortality. However, the associations of serum creatinine and cystatin C with muscle mass and mortality remain unclear and require further investigation to better inform clinical decision-making.

Methods

We included 8437 community-dwelling adults enrolled in the Dutch PREVEND study and 5033 in the US NHANES replication cohort. Associations of serum creatinine and/or cystatin C with muscle mass surrogates and mortality were quantified with linear and Cox proportional hazards regression, respectively. Missin

SUBMITTER: Groothof D 

PROVIDER: S-EPMC11294032 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature