Adiponectin-to-leptin ratio and incident chronic kidney disease: Sex and body composition-dependent association.

ABSTRACT:

Background

The association between the adiponectin-to-leptin ratio (A/L ratio) and the risk of incident chronic kidney disease (CKD) is poorly understood. This study aimed to investigate the association between A/L ratio and the risk of incident CKD and to examine whether such a relationship varied according to sex and body composition.

Methods

In this prospective community-based cohort, participants with normal kidney function were analysed (N = 5192). The association between the A/L ratio at baseline and the risk of incident CKD, defined as two or more occasions with an estimated glomerular filtration rate of <60 mL/min/m² or proteinuria of ≥1+ on a dipstick test during the follow-up period, was evaluated using multivariable Cox proportional hazards analyses. Su

SUBMITTER: Park HS 

PROVIDER: S-EPMC11294033 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature