Assessing the role of statin therapy in bladder cancer: evidence from a Mendelian Randomization study.

ABSTRACT:

Background

Statins, which are medications that lower lipid levels, are extensively used to decrease cardiovascular disease risk. Recently, the use of statins in cancer prevention has attracted considerable interest. However, it is still unclear whether the use of statins has a causal effect on bladder cancer.

Methods

The two-sample Mendelian Randomization (MR) was performed to infer the causal relationship between statin therapy (atorvastatin, simvastatin, and rosuvastatin) and bladder cancer. Single-nucleotide polymorphisms (SNP)-based genome-wide association studies (GWAS) of statins (atorvastatin, simvastatin, and rosuvastatin) were gathered from the UK Biobank, involving 462,933 participants. We acquired summary-level genetic data on bladder cancer from a European cohort

SUBMITTER: Li R 

PROVIDER: S-EPMC11294080 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature