A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells.

ABSTRACT: The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood-brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases including vascular cognitive impairment and Alzheimer's disease. Growing knowledge in the field of epigenetics can enhance the understanding of molecular profile of the BBB and has great potential for the development of novel therapeutic strategies or targets to repair a disrupted BBB. Histone deacetylases (HDACs) inhibitors are epigenetic regulators that can induce acetylation of histones and induce open chromatin conformation, promoting gene expression by enhancing the binding of DNA with transcription factors. We investigated how HDAC inhibition in

SUBMITTER: Inoue Y 

PROVIDER: S-EPMC11294206 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature