Cilostazol is a promising anti-pseudomonal virulence drug by disruption of quorum sensing.

ABSTRACT: Resistance to antibiotics is a critical growing public health problem that desires urgent action to combat. To avoid the stress on bacterial growth that evokes the resistance development, anti-virulence agents can be an attractive strategy as they do not target bacterial growth. Quorum sensing (QS) systems play main roles in controlling the production of diverse virulence factors and biofilm formation in bacteria. Thus, interfering with QS systems could result in mitigation of the bacterial virulence. Cilostazol is an antiplatelet and a vasodilator FDA approved drug. This study aimed to evaluate the anti-virulence activities of cilostazol in the light of its possible interference with QS systems in Pseudomonas aeruginosa. Additionally, the study examines cilostazol's impact on the bacteriu

SUBMITTER: Al-Rabia MW 

PROVIDER: S-EPMC11294311 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature