Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences.

ABSTRACT:

Background

Air pollution is ubiquitous, yet questions remain regarding its impact on the developing brain. Large changes occur in white matter microstructure across adolescence, with notable differences by sex.

Methods

We investigate sex-stratified effects of annual exposure to fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), and ozone (O₃) at ages 9-10 years on longitudinal patterns of white matter microstructure over a 2-year period. Diffusion-weighted imaging was collected on 3T MRI scanners for 8182 participants (1-2 scans per subject; 45% with two scans) from the Adolescent Brain Cognitive Development (ABCD) Study®. Restriction spectrum imaging was performed to quantify intracellular isotropic (RNI) and directional (RND) diffusio

SUBMITTER: Cotter DL 

PROVIDER: S-EPMC11294340 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature