Cholestyramine alleviates bone and muscle loss in irritable bowel syndrome via regulating bile acid metabolism.

ABSTRACT: Irritable bowel syndrome (IBS) is a widespread gastrointestinal disorder known for its multifaceted pathogenesis and varied extraintestinal manifestations, yet its implications for bone and muscle health are underexplored. Recent studies suggest a link between IBS and musculoskeletal disorders, but a comprehensive understanding remains elusive, especially concerning the role of bile acids (BAs) in this context. This study aimed to elucidate the potential contribution of IBS to bone and muscle deterioration via alterations in gut microbiota and BA profiles, hypothesizing that cholestyramine could counteract these adverse effects. We employed a mouse model to characterize IBS and analysed its impact on bone and muscle health. Our results revealed that IBS promotes bone and muscle loss, accom

SUBMITTER: Chen M 

PROVIDER: S-EPMC11294414 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature